Published hormone-inducible fusion proteins

(updated 8/97)

References

 

Protein 

Type of protein 

Receptor fuseda

Systemb

References 

DNA binding proteins

GAL4, GAL4-VP16

zinc finger

ER, ER*

tc

(Braselmann et al., 1993; Louvion et al., 1993)

GATA-1,2,3

zinc finger

ER

tc

(Briegel et al., 1993)

HNF4

nuclear receptor/zinc finger

ER

tc

(Drewes et al., 1994)

adenovirus E1A

zinc finger

ER,GR

tc

(Becker et al., 1989; Mattioni et al., 1994; Picard et al., 1988)

fos family

leucine zipper

ER

tc

(Schuermann et al., 1993; Superti-Fugara et al., 1991)

jun family

leucine zipper

ER

tc

(Fialka et al., 1996; Francis et al., 1995; Mattioni et al., 1994)

GCN4

leucine zipper

MR

yeast

(Fankhauser et al., 1994)

C/EBP

CCAAT BP

ER, GR

tc

(Mattioni et al., 1994; Umek et al., 1991)

rel

NFkB family

ER

tc

(Boehmelt et al., 1992; Mattioni et al., 1994)

myc

HLH

ER,ER*, GR

tc

(Eilers et al., 1989; Littlewood et al., 1995; Tikhonenko et al., 1995)

myoD

HLH

GR, ER, TR

tc; Xenopus

(Hollenberg et al., 1993; Kolm and Sive, 1995)

HNF3

forkhead domain

ER

tc

(Drewes et al., 1994)

otx-2

homeodomain

GR

Xenopus

(Gammill and Sive, 1997)

LFB1/HNF1

homeodomain

ER

tc

(Drewes et al., 1994)

brachyury

T-box

GR

Xenopus

(Tada et al., 1997)

myb

DNA binding

ER

tc

(Burk and Klempnauer, 1991)

p53

DNA binding,

ER*

tc

(Mattioni et al., 1994; Vater et al., 1996)

Epstein-Barr virus EBNA1; EBNA2

DNA binding

ER

tc

(Kempkes et al., 1995; Middleton and Sugden, 1992)

RNA binding proteins

HIV Rev

RNA binding

GR

tc

(Hope et al., 1990)

HTLV-1 Rex

RNA binding

ER

tc

(Rehberger et al., 1997)

Cell Cycle Regulators

adenovirus E1A

ER

tc

(Mattioni et al., 1994; Picard et al., 1988)

p53

ER*

tc

(Mattioni et al., 1994; Vater et al., 1996)

Kinases

c-abl

tyrosine kinase

ER

tc

(Jackson et al., 1993; Mattioni et al., 1994)

raf-1

serine/threonine kinase

ER

tc

(Mattioni et al., 1994; Samuels et al., 1993)

STE11

MAPKKK

ER

tc

(Mattioni et al., 1994)

Enzymes and other

methyltransferase

ER

tc

(Ishibashi et al., 1994)

FLP recombinase

ER,GR

tc

(Logie and Stewart, 1995)

Cre recombinase

ER, ER*, PR*

tc, mice

(Kellendonk et al., 1996; Metzger et al., 1995; Zhang et al., 1996)

LexA repressor

GR, TR

tc

(Godowski et al., 1988; Lee et al., 1994)

Transmembrane Proteins

fas

TNFR family

ER, RAR, EcR

tc, mice

(Takebayashi et al., 1996)

a. AR: androgen receptor; ER: estrogen receptor; ER*: mutated estrogen receptor; EcR: ecdysone receptor; GR: glucocorticoid receptor; MR: mineralocorticoid receptor; PR: progesterone receptor; PR*: mutated progesterone receptor; RAR: retinoic acid receptor; TR: thyroid hormone receptor

b.tc: tissue culture